Recent research and authoritative sources confirm that exposure to toxic chemicals like benzene can damage bone marrow cells, disrupt the production of healthy blood cells, and significantly increase the risk of myelodysplastic syndrome (MDS).
MDS is a rare group of disorders caused by abnormal development of very immature blood cells in the marrow, impairing the growth of healthy red blood cells, white blood cells, and platelets.
In many patients, especially those with prolonged railroad work, MDS eventually develops and may progress into acute myeloid leukemia (AML), with about one in three patients following this course.
Railroad workers face occupational exposure to industrial chemicals (most significantly benzene from diesel fuel, solvents, and other sources) that are well-established risk factors for MDS.
Studies have shown that blood stem cells in individuals exposed to benzene undergo DNA damage, impairing their ability to mature and compromising the immune system.
As a result, affected workers experience recurrent infections, bleeding tendencies, and general weakness due to inadequate cell count.
Because MDS impairs lung and organ function, life expectancy is often reduced unless aggressive treatment is pursued.
The link between industrial chemical exposure and bone marrow damage is supported by animal studies and epidemiological data, highlighting the toxic effects of long-term inhalation or skin contact.
Chemicals and settings linked to MDS in railroad workers include:
- Benzene in diesel exhaust and degreasers — linked to direct bone marrow toxicity and blood disorders
- Solvent mixtures (incl. trichloroethylene and perchloroethylene) used in shops — associated with hematologic mutations
- Diesel exhaust particles containing trace benzene and volatile organics — inhaled over years in locomotive cabs
- Degreasing solvents and fuels used by carmen and shop workers — repeated dermal and respiratory exposure
- Herbicides and pesticides used in track maintenance containing benzene derivatives — contact risk
- Silica or creosote dust combined with other chemicals may amplify bone marrow damage
Railroad workers who developed MDS as a result of on-the-job exposure deserve justice and compensation.
These serious conditions often go unrecognized until late in the disease course, but the connection to railroad occupational exposure may support a viable FELA claim.
Victims and their families may recover for medical costs, lost earnings, pain and suffering, and reduced life expectancy when backed by strong legal evidence.
Railroad Jobs Linked to an Increased Risk of Myelodysplastic Syndromes
Railroad workers in certain job roles may face heightened exposure to heavy metals, tobacco smoke, and certain chemicals that disrupt healthy blood production.
These exposures can damage the bone marrow and contribute to the development of myelodysplastic syndromes (MDS), a condition that often leads to acute leukemia.
While many of these chemicals are essential to railroad operations (such as degreasers, fuels, and solvents), repeated or prolonged exposure without adequate protection significantly increases health risks.
Jobs that involve maintenance work, shop environments, or close contact with locomotives are especially concerning.
Below are some of the railroad positions most commonly linked to MDS:
- Locomotive Engineers – routinely work in enclosed spaces with diesel exhaust, which contains benzene and other harmful chemicals.
- Conductors – often spend long hours around idling engines and fuel sources, increasing exposure to toxic fumes.
- Railroad Carmen – handle degreasers, fuel oils, and solvent mixtures during inspections and repairs.
- Track Maintenance Workers – apply herbicides and handle treated ties, often encountering chemical dust and vapors.
- Shopmen and Mechanics – clean and repair metal components using industrial solvents that may contain benzene or other hematotoxic substances.
- Signal Maintainers – may use solvent-based cleaners in confined electrical spaces with poor ventilation.
- Welders and Fabricators – frequently exposed to heavy metals and chemical fumes during repair and fabrication.
- Inspectors – involved in checking brake systems and engine parts, often using cleaning agents that contain certain chemicals harmful to blood-forming tissues.
These roles all present unique environmental and chemical hazards that may increase the risk of MDS and related illnesses in railroad employees.