Lymphoma is a cancer of the immune system that develops when white blood cells grow uncontrollably, and evidence shows that railroad work created the conditions for this disease to take hold.
For decades, employees were regularly exposed to dangerous chemicals such as benzene, trichloroethylene (TCE), perchloroethylene (PCE), polychlorinated biphenyls (PCBs), herbicides, and creosote: all known or suspected cancer causing substances.
These exposures disrupted normal immune function and damaged bone marrow, two recognized risk factors for lymphoma.
Research consistently links non-Hodgkin’s lymphoma to significant exposure to benzene, TCE, and certain herbicides, while Hodgkin lymphoma has also been tied to occupational environments where multiple toxic agents accumulate.
Railroad employees often experienced daily contact with solvents during repair work, herbicide sprays during track maintenance, and fumes from diesel fuel and creosote-treated ties.
Each of these exposures alone can raise cancer risk, but the overlap of many agents created an elevated risk for workers with long years of service.
Studies of industrial and transportation workers show that the types of exposures common in rail environments correlate with higher lymphoma rates compared to the general population.
Whether maintaining locomotives, cleaning train cars, or handling electrical equipment containing PCBs, workers faced hazards without being warned of the long-term consequences.
Today, both non-Hodgkin’s lymphoma and Hodgkin lymphoma are increasingly recognized as occupational cancers when linked to rail duties.
By documenting a history of chemical contact and cumulative dose, affected workers and families can connect their diagnosis to railroad service and pursue justice under the Federal Employers Liability Act (FELA).
Toxic Exposures on the Railroad Potentially Linked to Lymphoma
Railroad employees often encountered a toxic mix of agents that directly affected the immune system and blood-forming tissues.
Many of these exposures occurred daily in shops, yards, and along the tracks, where workers handled degreasers, inhaled exhaust, or applied herbicides with little protective equipment.
Over time, the cumulative effect of these dangerous chemicals disrupted normal cell growth and increased the likelihood of both non-Hodgkin’s lymphoma and Hodgkin lymphoma.
Workers with significant exposure histories, especially those who spent decades repairing locomotives, spraying weeds, or handling electrical equipment, face an elevated risk of lymphoma that medical science now ties to specific railroad duties.
Substances and exposures linked to lymphoma in railroad work include:
- Benzene exposure – Found in diesel fuel, exhaust, and solvents; one of the strongest occupational risk factors for non-Hodgkin’s lymphoma.
- Trichloroethylene (TCE) – A degreasing solvent widely used in rail shops, associated with increased risks of lymphoma in epidemiological studies.
- Perchloroethylene (PCE) – Another solvent used in cleaning and maintenance, linked to lymphatic cancers.
- Polychlorinated biphenyls (PCBs) – Present in older electrical equipment and fluids, associated with immune disruption and higher rates of non-Hodgkin’s lymphoma.
- Herbicides and weed killers (including glyphosate) – Applied during track maintenance to control vegetation, linked to elevated risks of non-Hodgkin’s lymphoma.
- Creosote and coal-tar products – Used on railroad ties and bridge timbers, containing PAHs that damage immune and lymphatic systems.
- Diesel exhaust and fuel vapors – Though most strongly tied to lung disease, they contribute benzene and PAH exposures that compound lymphoma risk.
This overlapping exposure environment meant that many railroad workers were not just exposed to one carcinogen, but to several at the same time, often for years on end.
Such cumulative contact significantly increases cancer risk, particularly for lymphomas that are sensitive to chemical disruption of the immune system.
Scientific Studies on the Links Between Lymphoma and Occupational Exposure
Decades of occupational epidemiology show that certain workplace chemicals can damage bone marrow and dysregulate the immune system (key biological pathways for lymphomas) especially after significant exposure over many years.
The most consistent human evidence concerns benzene, followed by chlorinated solvents such as trichloroethylene (TCE) and perchloroethylene (PCE), legacy electrical oils (PCBs), and some weed killers (notably glyphosate).
These findings come from large cohort and case–control studies, meta-analyses, and agency evaluations (IARC, EPA, NTP), and they mirror exposure patterns seen across transportation, manufacturing, utilities, and right-of-way maintenance jobs.
Importantly, for diesel exhaust, the modern synthesis finds no overall increase in NHL by itself, so diesel is best treated as a co-exposure (a source of benzene and PAHs) rather than a primary NHL driver.
Studies on occupational exposure and lymphoma include:
- Benzene – NHL (systematic review & meta-analysis, Lancet Planetary Health, 2019): Pooled human studies show a positive association between benzene exposure and non-Hodgkin lymphoma, with higher risks at higher exposures (dose-response). This builds on IARC’s benzene monograph.
- TCE (trichloroethylene) – NHL (meta-analyses; NTP/EPA): Occupational meta-analyses report elevated NHL risks among TCE-exposed workers; the U.S. NTP profile calls the human evidence limited but positive, and EPA’s IRIS lists NHL among TCE-associated tumor sites.
- PCE (perchloroethylene) – NHL (systematic review; EPA): Reviews of dry-cleaning and related cohorts find associations with NHL; EPA’s risk-evaluation materials summarize human studies considered in dose–response assessments.
- Glyphosate (weed killers) – NHL (meta-analysis; agency views): A 2019 meta-analysis reports increased NHL risk at the highest cumulative exposures; IARC classifies glyphosate as “probably carcinogenic” (2A), while EPA’s technical review takes a more conservative stance—useful context when presenting evidence in court.
- PAH-rich mixtures (creosote/coal-tar; occupational PAHs) – lymphatic/hematopoietic cancers: Systematic review of PAH-exposed workers shows excess risks across lymphatic/hematopoietic sites, consistent with ATSDR toxicology for creosote/PAHs as genotoxic mixtures.
- Diesel exhaust – NHL (systematic review & meta-analysis, 2022): Pooled data from 23 studies found no overall evidence of increased NHL from diesel exposure—supporting the view that diesel is more relevant as a co-exposure (benzene, PAHs) than a stand-alone NHL cause.
Although many studies are not railroad-specific, the exposure profiles they analyze (benzene-containing fuels/solvents, TCE/PCE degreasing, PCB-laden electrical oils, glyphosate-based weed control, and PAH-rich creosote) map directly onto historical rail tasks (operating locomotives and train cars, shop degreasing/parts washing, transformer/ballast work, and right-of-way weed killers).
Railroad Job Roles at an Increased Risk of Occupational Exposure
Lymphoma risk in the railroad industry is closely tied to the daily tasks that left employees surrounded by hazardous substances for years at a time.
Many railroad personnel worked in environments where diesel engines ran constantly, solvents were used to clean parts, and electrical equipment contained toxic oils and chemicals.
Long-term exposure and, in many cases, prolonged exposure to fuels, solvents, herbicides, and insulation materials created a higher risk of immune system damage that can lead to lymphoma.
Both operating crews and shop-based employees were affected, with shop workers and craft trades often facing especially high levels of chemical contact.
Job roles most at risk include:
- Engineers and Conductors spent long shifts in locomotive cabs with constant fumes from diesel engines.
- Sheet Metal Workers regularly cut, welded, and fabricated parts, creating metal fumes and frequent solvent use.
- Machinists and Shop Workers operated with degreasers, hazardous substances, and vaporized solvents in enclosed spaces.
- Electricians often handled electrical components containing PCBs and worked with solvents for cleaning and maintenance.
- Car Repairmen (Carmen) serviced brakes, bearings, and couplings with high potential for contact with solvents, oils, and asbestos-containing materials.
- Track Maintenance Crews used herbicides and creosote-treated ties, creating regular contact with toxic chemicals during repairs.
- Yard Workers and Switchmen constantly exposed to diesel exhaust and vapors while working near idling locomotives.
These positions highlight how exposure risks were spread across many roles, not just confined to a single type of worker.
Whether in a shop, along the tracks, or in the cab of a locomotive, railroad employees with prolonged exposure to multiple toxins face a documented elevated risk of lymphoma and other occupational illnesses.
Can Family Members File a Wrongful Death Lawsuit for a Loved One Who Passed Away from Lymphoma?
Yes, family members may pursue a wrongful death lawsuit if their loved one developed lymphoma after years of toxic railroad exposures.
Courts recognize that long-term exposure and, in many cases, prolonged exposure to fuels, solvents, herbicides, and other hazardous agents in rail work can directly contribute to this disease.
The worker’s employment status at the time of death (whether active, retired, or separated from the railroad) does not prevent families from seeking justice.
Wrongful death claims may help recover compensation for medical bills, funeral costs, lost income, and the loss of companionship.
By connecting medical records with documented histories of chemical contact, families can show that a preventable occupational illness caused their loved one’s death.
Through the Federal Employers Liability Act (FELA), survivors have a legal path to hold railroad companies accountable for unsafe conditions that led to a devastating loss.