For decades, railroad employees have faced daily contact with dangerous chemicals without proper safety precautions.
These toxic exposures occurred in locomotive cabs, switching yards, and repair shops where fuels, degreasers, and solvents were a routine part of the job.
Scientific research shows that long-term exposure to substances such as benzene, diesel exhaust, and trichloroethylene can damage bone marrow and blood-forming cells, causing cancer of the blood and immune system.
Despite growing evidence of harm, many railroad companies failed to warn workers about the risks, leaving employees with an elevated cancer risk years after the exposures occurred.
Types of blood cancer commonly linked to railroad work include:
- Leukemia (especially Acute Myeloid Leukemia, AML): Strongly associated with benzene exposure in fuels and diesel exhaust; results from damage to bone marrow cells after years of significant exposure.
- Non-Hodgkin Lymphoma (NHL): Linked to trichloroethylene (TCE), herbicides, and diesel-related chemicals; develops in lymphatic tissues and often tied to long-term exposure.
- Hodgkin Lymphoma: Less common but reported among railroad workers; linked to solvent exposure and immune system disruption from chronic toxic contact.
- Multiple Myeloma: Associated with prolonged exposure to benzene and certain hydrocarbons; affects plasma cells and weakens the body’s ability to fight infection.
- Myelodysplastic Syndromes (MDS): Considered an occupational illness tied to chronic benzene exposure; may progress to leukemia after years of working around fuels and solvents.
The railroad industry has created environments where significant exposure was unavoidable, from workers breathing in diesel fumes to mechanics handling degreasers daily without protective equipment.
Over time, these exposures weakened immune systems, disrupted bone marrow, and increased the likelihood of cancer diagnoses that appear decades later.
Blood cancers in railroad workers are not random.
They reflect a pattern of toxic contact that was preventable if rail companies had acted sooner to protect and warn workers.
By connecting the history of occupational illness to the chemicals used in rail operations, victims and their families can show that employment conditions directly contributed to the development of life-altering diseases.
Scientific Research Supporting Blood Cancer Claims in Railroad Workers
The most persuasive science in railroad blood-cancer cases centers on benzene (in fuels, parts-washing, and as a combustion component), with additional support for trichloroethylene (TCE) used historically as a degreaser.
Authoritative agencies classify benzene as a known human carcinogen that causes leukemia, and regulatory materials document marrow toxicity and medical-surveillance requirements: evidence that hazards were foreseeable and controllable.
Diesel exhaust is the dominant lung cancer risk in rail cohorts; for leukemia, recent pooled cohort analyses judge the association with diesel itself as not well established, which is why benzene and certain solvents are the primary exposure theories in blood-cancer claims.
Studies and literature on blood cancer and occupational exposures include the following:
- IARC Monographs (Vol. 120, 2018) – Benzene: Confirms Group 1 (carcinogenic to humans) with sufficient evidence for leukemia in humans, supported by animal and mechanistic data. Use as the cornerstone classification for benzene in rail settings.
- Lan et al., Science (2004) – Hematotoxicity at low levels: Demonstrated bone-marrow and blood-cell toxicity at sub-ppm to tens-of-ppm benzene, establishing a biologic bridge from exposure to leukemogenesis.
- Hayes/Yin et al., JNCI (1997) – Chinese benzene cohort: Large retrospective cohort with dose–response increases in hematologic neoplasms as cumulative benzene exposure rose.
- Vermeulen/Linet/Lan et al., JNCI (2019) – Case-cohort update (110,631 workers): Found exposure–response for MDS/AML and evaluated timing/age patterns of risk; strengthens causal links beyond AML to MDS. Open-access summary available.
- OSHA Benzene Standard (29 CFR 1910.1028 & App. C): Requires monitoring and medical surveillance; recognizes benzene’s capacity to cause aplastic anemia and leukemia, probative on notice and duty to protect.
- Diesel exhaust & leukemia (2023 cohort meta-analysis): Concludes the leukemia link to diesel exhaust is not well established, guiding strategy to emphasize benzene/solvent pathways rather than diesel particulate per se.
- U.S. railroad diesel cohorts (Garshick/Laden et al.): Show elevated lung-cancer mortality in diesel-exposed operating crafts, quantifying intense, chronic exposure typical of legacy rail eras; useful context for reconstructing total inhalation burden alongside benzene.
Railroad Jobs at Risk for Exposure to Dangerous Substances Linked to Blood Cancer
Throughout the history of the railroad industry, certain jobs placed workers in direct contact with dangerous substances known to damage bone marrow and blood cells.
In many cases, these exposures occurred daily, creating a pattern of long-term exposure that significantly raised the chance of developing leukemia, lymphoma, or multiple myeloma.
Workers often handled fuels, solvents, and degreasers without protective gear, leaving them with a heightened cancer risk that could have been reduced if companies had acted to warn workers.
Affected workers in both the rail yards and the repair shops are consistently documented as having the highest levels of toxic exposures.
These positions highlight how the structure of the railroad industry created unavoidable risks for many employees.
Railroad employees frequently exposed to toxic chemicals include:
- Engineers and conductors spent long shifts in locomotive cabs filled with diesel exhaust and fuel vapors
- Machinists operated in shops using solvents, degreasers, and lubricants with benzene content
- Pipefitters and boilermakers worked with cleaning agents and fuels that produced benzene exposure
- Car repairmen regularly handled adhesives, paints, and degreasing solutions
- Track maintenance crews exposed to herbicides, creosote-treated ties, and diesel fumes from equipment
- Yard workers and switchmen faced constant inhalation of diesel exhaust during train assembly operations
- Sheet metal workers frequently welded, cut, and fabricated parts while breathing in fumes containing metals and solvents tied to blood cancers
Railroad occupational exposure was not limited to one role, and many employees were regularly exposed to multiple toxins over the course of their careers.
This overlapping chemical burden greatly increased the chance of developing cancer years or even decades after active railroad service ended.
Can I File a Wrongful Death Lawsuit if My Loved One Passed Away of Blood Cancer?
Yes, family members may be able to bring a wrongful death claim if a loved one developed blood cancer due to toxic exposures while working for a railroad employer.
These lawsuits recognize that cancer often shortens a worker’s life expectancy, leaving families with financial and emotional losses.
Under the Federal Employers Liability Act (FELA), survivors can pursue claims to obtain compensation for medical expenses, funeral costs, and loss of support.
Spouses, children, or other dependents are generally eligible to file, depending on the circumstances.
A wrongful death lawsuit also holds the railroad accountable for failing to protect workers from preventable hazards.
For many families, this type of claim provides both financial security and acknowledgment of the harm caused by unsafe railroad conditions.