Railroad workers have historically faced daily contact with dangerous substances while operating locomotives, repairing equipment, and maintaining tracks.
One of the most widely studied hazards is diesel exhaust exposure, which occurs in locomotive cabs, rail yards, and enclosed shop environments.
Prolonged exposure to diesel exhaust subjects workers to a mix of carcinogenic compounds, including benzene, polycyclic aromatic hydrocarbons (PAHs), and formaldehyde.
Epidemiological studies demonstrate that long-term diesel exposure is associated with an increased cancer risk, not only for lung cancer but also for cancers of the urinary tract such as bladder cancer .
Railroad employees often faced workplace exposures without adequate ventilation or protective equipment, leading to decades of significant exposure.
These exposures are cumulative, and the risk of illness typically increases with both intensity and duration of contact.
Benzene exposure, in particular, has been implicated in numerous occupational cancer cases and remains a central factor in litigation involving railroad workers.
The evidence makes clear that long-term work in the railroad industry can place employees at a higher risk of developing bladder cancer.
Chemicals and exposures linked to bladder cancer in railroad workers include:
- Diesel exhaust – Classified by IARC as a Group 1 carcinogen; linked to bladder and lung cancer in transport-sector workers .
- Benzene exposure – Present in fuels, lubricants, and solvents; associated with multiple cancers including bladder cancer .
- Polycyclic aromatic hydrocarbons (PAHs) – Found in diesel exhaust and coal-tar creosote; associated with elevated bladder cancer risk .
- Creosote and coal-tar derivatives – Used to preserve railroad ties; contain high levels of PAHs that can damage the bladder lining .
- Chlorinated solvents (PCE, TCE) – Historically used as degreasers in rail shops; linked to increased incidence of bladder cancer .
- Welding fumes (arsenic, cadmium, chromium compounds) – Inhaled during track and car repairs; contain metals tied to bladder cancer .
- Silica dust – Generated during ballast and track work; recognized occupational carcinogen with bladder cancer associations .
The railroad environment exposed workers to a unique combination of dangerous substances, often simultaneously, creating layered health risks.
While smoking is an independent risk factor for bladder cancer, occupational evidence shows that chemical exposures in rail work act as additional drivers of disease and can worsen the effects of tobacco.
The long latency period (often several decades) means that many diagnoses appear well after retirement, making the connection to railroad employment less obvious without a medical and occupational history review.
Under the Federal Employers Liability Act (FELA), rail companies can be held responsible when workplace exposures play a role in serious illness, even when other factors are present.
For workers who spent years in jobs with significant exposure to diesel fumes, solvents, or creosote, a diagnosis of bladder cancer may be directly tied to the conditions of employment in the railroad industry.
Scientific Studies Linking Railroad Work to Bladder Cancer
Across occupational epidemiology, the clearest bladder-cancer signals map to exposures that are commonplace in rail settings: diesel exhaust (a complex mixture rich in PAHs and nitro-PAHs), PAH-containing creosote/coal-tar products, chlorinated solvents used in shops (notably PCE), and historically, aromatic amines in coatings and industrial materials.
In 2012, the WHO’s International Agency for Research on Cancer (IARC) classified diesel engine exhaust as carcinogenic to humans (Group 1); while the evidence for lung cancer was “sufficient,” IARC also reported a positive association (limited evidence) with increased bladder cancer risk, a finding highly relevant to transportation workers that include railroad crafts.
Subsequent pooled case–control work that reconstructed lifetime occupational diesel exposure found that higher cumulative exposure (measured with respirable elemental carbon proxies) was associated with elevated urothelial bladder cancer risk, with signals persisting after lag analyses and varying by pathologic stage/grade.
Beyond diesel, a large systematic review/meta-analysis in JAMA Oncology confirmed that aromatic amines drive some of the highest occupational bladder-cancer risks, and that PAH-intense exposures are associated with worse mortality, mechanisms that fit rail tasks involving creosote-treated ties and fume-heavy repair work.
ATSDR training materials similarly summarize human data linking occupational PAH exposure with increased incidences of bladder (and other) cancers, reinforcing concern where creosote/coal-tar and diesel are routine.
Shop environments add a solvent pathway: a meta-analysis in Environmental Health Perspectives reported increased bladder cancer risk among workers exposed to tetrachloroethylene (PCE) (a degreaser historically used in rail shops) supporting inhalational/dermal solvent exposure as a plausible contributor.
Classic and updated dyestuff worker cohorts document decades-long excess bladder-cancer mortality after heavy aromatic amine exposure, offering strong human mechanistic precedent for arylamine-driven urothelial carcinogenesis that can inform rail causation analyses.
Railroad Jobs Linked to an Increased Risk of Toxic Exposure and Bladder Cancer
Railroad jobs often placed affected workers in environments filled with dangerous chemicals, fumes, and dust.
Employees in certain crafts were frequently exposed to diesel exhaust, solvents, and creosote while performing everyday duties.
For some, even short-term exposure led to immediate health effects such as respiratory irritation, while others faced the compounded risks of long-term exposure that developed silently over decades.
Sheet metal workers, machinists, and track crews were particularly vulnerable due to direct contact with fuels, paints, and welding fumes.
The railroad company environment often lacked adequate protective gear and safety controls, heightening the risk for these groups.
Ultimately, a wide range of rail occupations carry elevated risks for toxic exposure and the subsequent development of bladder cancer.
Job roles frequently exposed to toxic substances include:
- Sheet metal workers – handled solvents, welding fumes, and paints daily
- Machinists – operated in shops with heavy diesel exhaust and chemical degreasers
- Conductors and engineers – spent long shifts in locomotive cabs filled with diesel exhaust
- Track maintenance crews – worked with creosote-treated ties, silica dust, and herbicides
- Pipefitters and boilermakers – came into contact with asbestos, solvents, and welding fumes
- Car repairmen – handled paints, lubricants, and adhesives containing toxic compounds
- Yard workers – endured constant exposure to diesel fumes in switching yards
Can I File a Wrongful Death Lawsuit if My Loved One Passed Away of Bladder Cancer?
Yes, you may be able to potentially file a wrongful death lawsuit if your loved one passed away from bladder cancer that was connected to railroad work.
Families of railroad employees who suffered from long-term toxic exposures may have rights under the Federal Employers Liability Act (FELA).
This law allows surviving spouses, children, or other dependents to pursue compensation when a railroad company failed to provide a reasonably safe workplace.
If your loved one endured years of diesel exhaust exposure, benzene exposure, or contact with dangerous chemicals, that history may establish a basis for liability.
Even if cigarette smoke or other health factors were present, courts recognize that workplace exposures can still play a significant role in causing or accelerating cancer.
A wrongful death claim can seek damages for lost financial support, medical costs, and the pain and suffering endured by the family.
Consulting an experienced railroad cancer lawyer can help determine if your family has grounds to move forward with this type of lawsuit.